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Human PDE6A protein

SKU
Name
Human PDE6A protein
Size
50 ug
Price
$398.00
Qty

Human PDE6A protein

Description
Recombinant protein from the full-length sequence of homo sapiens phosphodiesterase 6A (PDE6A) (NM_000440), with a His tag.
Host
Human Cells
Tags
His
RefSeq Link
NM_000440; NP_000431; UniProt#: P16499; GeneID: 5145;
Synonyms
CGPR-A; PDEA; RP43
Molecular Weight
99.4 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008].

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