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Human SEC31A protein

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Human SEC31A protein
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Human SEC31A protein

Description Recombinant protein from the full-length sequence of homo sapiens SEC31 homolog A, COPII coat complex component (SEC31A), transcript variant 3 (NM_001077208), with a His tag.
Host Human cells
RefSeq Link NM_001077208; NP_001070676; UniProt#: O94979; GeneID: 22872;
Synonyms ABP125; ABP130; HSPC275; HSPC334; SEC31L1
Molecular Weight 131.4 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
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