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Human INS protein

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Human INS protein
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Price
$398.00
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Human INS protein

Description
Recombinant protein from the full-length sequence of homo sapiens insulin (INS), transcript variant 1 (NM_000207), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_000207; NP_000198; UniProt#: P01308; GeneID: 3630;
Synonyms
IDDM; IDDM1; IDDM2; ILPR; IRDN; MODY10
Molecular Weight
9.3 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].

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