|Description||Recombinant protein from the full-length sequence of homo sapiens keratin 8 (KRT8), transcript variant 2 (NM_002273), with a His tag.|
|RefSeq Link||NM_002273; NP_002264; UniProt#: P05787; GeneID: 3856;|
|Synonyms||CARD2; CK-8; CK8; CYK8; K2C8; K8; KO|
|Molecular Weight||53.5 kDa|
|Purity||>90% by SDS-PAGE gel and Coomassie Blue staining|
|Applications||Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!|
|Formulation||Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives|
|Endotoxin||>Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)|
|Background||This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].|
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