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Human PTPRE protein

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Human PTPRE protein
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Human PTPRE protein

Description Recombinant protein from the full-length sequence of homo sapiens protein tyrosine phosphatase, receptor type E (PTPRE), transcript variant 1 (NM_006504), with a His tag.
Host Human cells
RefSeq Link NM_006504; NP_006495; UniProt#: P23469; GeneID: 5791;
Synonyms HPTPE; PTPE; R-PTP-EPSILON
Molecular Weight 80.5 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]
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