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Human FMR1 protein

SKU
Name
Human FMR1 protein
Size
50 ug
Price
$398.00
Qty

Human FMR1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens fragile X mental retardation 1 (FMR1), transcript variant ISO1 (NM_002024), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_002024; NP_002015; UniProt#: Q06787; GeneID: 2332;
Synonyms
FMRP; FRAXA; POF; POF1; POFX
Molecular Weight
71 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010].

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