×
Login

Human ACTN4 protein

SKU
Name
Human ACTN4 protein
Size
50 ug
Price
$398.00
Qty

Human ACTN4 protein

Description
Recombinant protein from the full-length sequence of homo sapiens actinin alpha 4 (ACTN4) (NM_004924), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_004924; NP_004915; UniProt#: O43707; GeneID: 81;
Synonyms
ACTININ-4; FSGS; FSGS1
Molecular Weight
104.7 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]

Contact Us
View Storefront

Related Products


There's no citations at this moment.


There's no FAQs at this moment.


There's no reviews at this moment.