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Human SNCB protein

SKU
Name
Human SNCB protein
Size
50 ug
Price
$398.00
Qty

Human SNCB protein

Description
Recombinant protein from the full-length sequence of homo sapiens synuclein beta (SNCB), transcript variant 2 (NM_003085), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_003085; NP_003076; UniProt#: Q16143; GeneID: 6620;
Synonyms
beta-synuclein; synuclein, beta
Molecular Weight
14.1 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. [UniProtKB/Swiss-Prot Function]

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