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Human SNCB protein

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Human SNCB protein
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Human SNCB protein

Description Recombinant protein from the full-length sequence of homo sapiens synuclein beta (SNCB), transcript variant 2 (NM_003085), with a His tag.
Host Human cells
RefSeq Link NM_003085; NP_003076; UniProt#: Q16143; GeneID: 6620;
Synonyms beta-synuclein; synuclein, beta
Molecular Weight 14.1 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. [UniProtKB/Swiss-Prot Function]
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