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Human PBX1 protein

SKU
Name
Human PBX1 protein
Size
50 ug
Price
$398.00
Qty

Human PBX1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens pre-B-cell leukemia homeobox 1 (PBX1), transcript variant 1 (NM_002585), with a His tag.
Host
Human cells
Tags
His
RefSeq Link
NM_002585; NP_002576; UniProt#: P40424; GeneID: 5087;
Synonyms
DKFZp686B09108; MGC126627
Molecular Weight
46.4 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

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