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Human PYCARD protein

SKU
Name
Human PYCARD protein
Size
50 ug
Price
$398.00
Qty

Human PYCARD protein

Description
Recombinant protein from the full-length sequence of homo sapiens PYD and CARD domain containing (PYCARD), transcript variant 1 (NM_013258), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_013258; NP_037390; UniProt#: Q9ULZ3; GeneID: 29108;
Synonyms
ASC; CARD5; TMS; TMS-1; TMS1
Molecular Weight
21.4 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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