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Human IGF1R protein

SKU
Name
Human IGF1R protein
Size
50 ug
Price
$398.00
Qty

Human IGF1R protein

Description
Recombinant protein from the full-length sequence of Homo sapiens insulin like growth factor 1 receptor (IGF1R), transcript variant 1 (NM_000875), with a His tag.
Host
Human Cells
Tags
His
RefSeq Link
NM_000875; NP_000866; UniProt#: P08069; GeneID: 3480;
Synonyms
CD221; IGFIR; IGFR; JTK13
Molecular Weight
154.8 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].

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