Human PDE1A protein
Recombinant protein from the full-length sequence of Homo sapiens phosphodiesterase 1A (PDE1A), transcript variant 1 (NM_005019), with a DYKDDDDK tag.
CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A
>90% by SDS-PAGE gel and Coomassie Blue staining
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulated in a sterile solution of 0.1M Glycine, Tris-buffered saline, pH7.4, without any preservatives
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009].
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