|Description||Recombinant protein from the full-length sequence of homo sapiens runt related transcription factor 1 (RUNX1), transcript variant 2 (NM_001001890), with a His tag.|
|RefSeq Link||NM_001001890; NP_001001890; UniProt#: Q01196; GeneID: 861;|
|Synonyms||AML1; AML1-EVI-1; AMLCR1; CBFA2; EVI-1; PEBP2aB|
|Molecular Weight||48.6 kDa|
|Purity||>90% by SDS-PAGE gel and Coomassie Blue staining|
|Applications||Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!|
|Formulation||Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives|
|Endotoxin||>Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)|
|Background||Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]|
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