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Human UHRF1 protein

SKU
Name
Human UHRF1 protein
Size
50 ug
Price
$398.00
Qty

Human UHRF1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens ubiquitin-like with PHD and ring finger domains 1 (UHRF1), transcript variant 1 (NM_001048201), with a His tag.
Host
Human cells
Tags
His
RefSeq Link
NM_001048201; NP_001041666; UniProt#: Q96T88; GeneID: 29128;
Synonyms
hNP95; hUHRF1; huNp95; ICBP90; Np95; RNF106
Molecular Weight
89.6 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

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