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Human PLCG1 protein

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Human PLCG1 protein
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Human PLCG1 protein

Description Recombinant protein from the full-length sequence of homo sapiens phospholipase C gamma 1 (PLCG1), transcript variant 1 (NM_002660), with a His tag.
Host Human cells
RefSeq Link NM_002660; NP_002651; UniProt#: P19174; GeneID: 5335;
Synonyms NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1
Molecular Weight 148.5 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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