| Description | Recombinant protein from the full-length sequence of homo sapiens nuclear mitotic apparatus protein 1 (NUMA1), transcript variant 1 (NM_006185), with a His tag. |
| Host | Human cells |
| RefSeq Link | NM_006185; NP_006176; UniProt#: Q14980; GeneID: 4926; |
| Synonyms | NMP-22; NUMA |
| Molecular Weight | 238.1 kDa |
| Purity | >90% by SDS-PAGE gel and Coomassie Blue staining |
| Applications | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Formulation | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg) |
| Background | This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] |
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