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Human ZAP70 protein

SKU
Name
Human ZAP70 protein
Size
50 ug
Price
$398.00
Qty

Human ZAP70 protein

Description
Recombinant protein from the full-length sequence of homo sapiens zeta chain of T cell receptor associated protein kinase 70 (ZAP70), transcript variant 1 (NM_001079), with a DYKDDDDK tag.
Host
Human cells
Tags
DYKDDDDK
RefSeq Link
NM_001079; NP_001070; UniProt#: Q8IZP9; GeneID: 7535;
Synonyms
SRK; STCD; STD; TZK; ZAP-70
Molecular Weight
69.7 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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