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Human PDX1 protein

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Name
Human PDX1 protein
Size
50 ug
Price
$398.00
Qty

Human PDX1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens pancreatic and duodenal homeobox 1 (PDX1) (NM_000209), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_000209; NP_000200; UniProt#: P52945; GeneID: 3651;
Synonyms
GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1
Molecular Weight
30.6 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. [UniProtKB/Swiss-Prot Function]

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