| Description | Recombinant protein from the full-length sequence of homo sapiens pancreatic and duodenal homeobox 1 (PDX1) (NM_000209), with a His tag. |
| Host | Human cells |
| RefSeq Link | NM_000209; NP_000200; UniProt#: P52945; GeneID: 3651; |
| Synonyms | GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1 |
| Molecular Weight | 30.6 kDa |
| Purity | >90% by SDS-PAGE gel and Coomassie Blue staining |
| Applications | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Formulation | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg) |
| Background | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. [UniProtKB/Swiss-Prot Function] |
There's no citations at this moment.
There's no FAQs at this moment.
There's no reviews at this moment.