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Human TP53 protein

SKU
Name
Human TP53 protein
Size
50 ug
Price
$398.00
Qty

Human TP53 protein

Description
Recombinant protein from the full-length sequence of homo sapiens tumor protein p53 (TP53), transcript variant 1 (NM_000546), with a DYKDDDDK tag.
Host
Human cells
Tags
DYKDDDDK
RefSeq Link
NM_000546; NP_000537; UniProt#: P04637; GeneID: 7157;
Synonyms
BCC7; LFS1; P53; TRP53
Molecular Weight
43.5 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

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