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Human ALAS1 protein

SKU
Name
Human ALAS1 protein
Size
50 ug
Price
$398.00
Qty

Human ALAS1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens 5'-aminolevulinate synthase 1 (ALAS1), transcript variant 2 (NM_199166), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_199166; NP_954635; UniProt#: P13196; GeneID: 211;
Synonyms
ALAS; ALAS-H; ALAS3; ALASH; MIG4
Molecular Weight
70.4 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

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