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Human INPP5D protein

SKU
Name
Human INPP5D protein
Size
50 ug
Price
$398.00
Qty

Human INPP5D protein

Description
Recombinant protein from the full-length sequence of homo sapiens inositol polyphosphate-5-phosphatase D (INPP5D), transcript variant 2 (NM_005541), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_005541; NP_005532; UniProt#: Q92835; GeneID: 3635;
Synonyms
hp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145
Molecular Weight
133 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014].

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