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Human DNMT1 protein

SKU
Name
Human DNMT1 protein
Size
50 ug
Price
$398.00
Qty

Human DNMT1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 1 (NM_001130823), with a His tag.
Host
Human cells
Tags
His
RefSeq Link
NM_001130823; NP_001124295; UniProt#: P26358; GeneID: 1786;
Synonyms
ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI; MCMT
Molecular Weight
184.6 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

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