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Human BAG3 protein

SKU
Name
Human BAG3 protein
Size
50 ug
Price
$398.00
Qty

Human BAG3 protein

Description
Recombinant protein from the full-length sequence of homo sapiens BCL2 associated athanogene 3 (BAG3) (NM_004281), with a His tag.
Host
Human cells
Tags
His
RefSeq Link
NM_004281; NP_004272; UniProt#: O95817; GeneID: 9531;
Synonyms
BAG-3; BIS; CAIR-1; MFM6
Molecular Weight
61.4 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008].

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