Human IDUA protein

Human IDUA protein

Human IDUA protein

Description Recombinant protein from the full-length sequence of homo sapiens iduronidase, alpha-L- (IDUA), transcript variant 1 (NM_000203), with a His tag.
Host Human cells
RefSeq Link NM_000203; NP_000194; UniProt#: P35475; GeneID: 3425;
Synonyms IDA; MPS1
Molecular Weight 70 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008].
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