| Description | Recombinant protein from the full-length sequence of homo sapiens iduronidase, alpha-L- (IDUA), transcript variant 1 (NM_000203), with a His tag. |
| Host | Human cells |
| RefSeq Link | NM_000203; NP_000194; UniProt#: P35475; GeneID: 3425; |
| Synonyms | IDA; MPS1 |
| Molecular Weight | 70 kDa |
| Purity | >90% by SDS-PAGE gel and Coomassie Blue staining |
| Applications | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Formulation | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg) |
| Background | This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]. |
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