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Human HLA-DQB2 protein

SKU
Name
Human HLA-DQB2 protein
Size
50 ug
Price
$398.00
Qty

Human HLA-DQB2 protein

Description
Recombinant protein from the full-length sequence of Homo sapiens major histocompatibility complex, class II, DQ beta 2 (HLA-DQB2-DQB2), transcript variant 2 (NM_001198858), with a DYKDDDDK tag.
Host
Human Cells
Tags
DYKDDDDK
RefSeq Link
NM_001198858; NP_001185787; UniProt#: P05538; GeneID: 3120;
Synonyms
HLA-DQB1; HLA-DXB
Molecular Weight
26.0 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus. [provided by RefSeq, Oct 2010]

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