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Human PD-L1 Protein

SKU
Name
Human PD-L1 Protein
Size
50 ug
Price
$398.00
Qty

Human PD-L1 Protein

Description
Recombinant protein from the extracellular domain (Phe19 - Arg238) of homo sapiens CD274 molecule (CD274), transcript variant 1 (NM_014143), with a rabbit IgG Fc tag.
Host
Human cells
Source
RefSeq Link
NM_014143; NP_054862; UniProt#: Q9NZQ7; GeneID: 29126;
Synonyms
B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1
Molecular Weight
41 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

SDS-Page Image
Fig 1 : SDS-Page Image
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