EUPROTEIN has developed high-quality human UCHL1 proteins that could be used for diagnostic assay development. Only $99 for 25ug!
Ubiquitin carboxy-terminal hydrolase L (UCHL1) is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is abundantly present in all neurons (accounts for 1-2% of total brain protein), expressed specifically in neurons and testis/ovary.
Dysfunction of UCHL1 has been reported in neurodegenerative diseases. An article published in 2014 has shown that UCHL1 may delay Alzheimer's disease progression by regulating amyloid β precursor protein (APP) degradation in a long-term fashion, and that overexpression of UCHL1 may be a safe and effective disease-modifying strategy to treat Alzheimer’s disease.
Similar to Glial fibrillary acidic protein (GFAP), UCHL1 has recently been proposed as a candidate biomarker for brain injury. UCHL1 can be released from injured neurons and flow into the cerebrospinal fluid and circulating blood, and thus is considered a diagnostic candidate for traumatic brain injury (TBI).
EUPROTEIN has developed high-quality human UCHL1 proteins that could be used for diagnostic assay development.
These proteins are on sale now, only $99 for 25ug! Place order now.
If you would like to express the UCHL1 or GFAP protein or generating antibodies against them, please submit your inquiry