The Kirsten Ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. The KRAS gene provides instructions for making a protein called K-Ras, part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate).
KRAS acts as a molecular on/off switch, using protein dynamics. Once it is allosterically activated, it recruits and activates proteins necessary for the propagation of growth factors, as well as other cell signaling receptors like c-Raf and PI 3-kinase.
EUPROTEIN has developed and validated KRAS proteins that could be used in the studies of oncogene drug development and/or immunoassay development.
If you need help expressing KRAS proteins or generating antibodies against them, please submit your inquiry by clicking the button below. Our service representative will get back to you promptly to discuss your project needs.