EUPROTEIN has developed and validated BVDV-Erns proteins that could be used in the studies of diagnostic assays or therapies involved with BVDV-Erns.
BVDVs are a members of the genus Pestivirus, belonging to the family Flaviviridae. Other members of this genus cause Border disease (sheep) and classical swine fever (pigs) which cause significant financial loss to the livestock industry. An unusual feature of pestiviruses is their ability to sustain a persistent infection after in utero infection of a fetus. BVDV exists as two biotypes according to their cytopathogenicity on cultured cells, and the ability to sustain a persistent infection is exclusively a property of the noncytopathogenic BVDV biotype.
BVD infection results in a wide variety of clinical signs, due to its immunosuppressive effects, as well as having a direct effect on respiratory disease and fertility. In addition, BVD infection of a susceptible dam during a certain period of gestation can result in the production of a persistently infected (PI) fetus. PI animals recognise intra-cellular BVD viral particles as ‘self’ and shed virus in large quantities throughout life; they represent the cornerstone of the success of BVD as a disease
BVD is considered one of the most significant infectious diseases in the livestock industry worldwide due to its high prevalence, persistence and clinical consequences.
EUPROTEIN has developed and validated BVDV proteins that could be used in assay development for diagnostic of BVDV, or potentially drug screening/therapeutic vaccine development. These high-quality proteins can also serve as references in immunoassay kits that quantify BVDV binding capabilities.
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