EUPROTEIN has developed high-quality bio-active human AMH proteins that could be used for AMH diagnostic assay development.
The anti-Mullerian hormone (AMH) gene, also known as Müllerian-Inhibiting Hormone (MIH), Müllerian Inhibiting Factor (MIF), Müllerian-Inhibiting Substance (MIS)), encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The AMH hormone is produced by reproductive tissues, including the testicles in males and the ovaries in females. The role of AMH and the amount normally present varies depending upon sex and age.
AMH is important for a woman during her childbearing years. At birth, a female has about one million eggs (oocytes), which then decrease naturally in number during childhood to about 500,000. Only a tiny number of these remaining eggs will go through follicle maturation – one at a time as part of a woman's monthly menstrual cycle. AMH has a balancing effect on the monthly cyclical actions of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) during the process of egg maturation and release (ovulation). The amount of AMH present is a reflection of this follicular growth.
An AMH test is often used to evaluate a woman’s fertility status as the AMH level has been shown useful in determining a woman's remaining egg maturation potential (ovarian reserve) and her likelihood of conceiving. AMH declines over time during childbearing years, drops significantly as menopause approaches, and typically becomes almost undetectable after menopause. Therefore, the AMH level may also be useful in predicting the onset of menopause.
Elevated AMH levels have been associated with a condition affecting the ovaries known as polycystic ovary syndrome (PCOS). The excess follicles that occur in this syndrome produce abnormally large amounts of AMH.
AMH also plays a vital part in sexual differentiation in the fetus. During the first few weeks of pregnancy, a developing baby has the potential to develop either male or female reproductive organs. Production of AMH and androgens by the two testicles that are present in a baby boy inhibits development of female reproductive organs and promotes the formation of other male reproductive organs. If a sufficient amount of AMH is not available or absent during this process, then both male and basic female organs may develop.
AMH may be elevated in some ovarian tumors (benign or cancerous). If a tumor produces the hormone, then the AMH test can be used as a tumor marker to monitor the effectiveness of treatment and to monitor for recurrence.
A blood test of the AMH level can be used to:
EUPROTEIN has developed high-quality bio-active human AMH proteins that could be used for AMH diagnostic assay development. Please refer to these beautiful product images below:
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